Micro-structured surfaces for aerostatic linear guideways are designed to reduce the gas resistance in high speed machine tools. Frist,an analysis model of micro-structured for air drag reduction is established based on the Reynolds averaged N-S equations and the Realizablek-ε turbulence model. Furthermore,the influencing of various factors on the micro-structured surfaces is identified through the four types of the micro-structures as case studies,by adopting the methods of drag reducing mechanism and simulation analysis,respectively. The four configurations are rectangular groove,V-shaped groove,U-shaped groove and Space-V groove surfaces. Among them,the most suitable groove surface for the ultra-precision machine tools is V-shaped groove surface. Finally,optimized analysis for the V-shaped groove surfaces is carried out using geometrical parameters including groove angle,width and gap,etc. The design study can be used to further ensure the design precision and movement accuracy for ultra-precision machine tools.