The tin interfacial layer(also known as immersion tin layer) plays a crucial role in the binding properties between the steel sleeve(low carbon steel) and the liner(Babbitt). The optimum thickness of tin interfacial layer can make the interface of steel sleeve and liner get the optimal binding strength. The orthogonal test of multi-factor levels is designed in consideration of influencing factors of the thickness of tin interfacial layer. And the formula that the thickness of tin interfacial layer depends on roughness, temperature, time and the number of times is established. The simulation analysis of interfacial binding energy between the steel sleeve and the liner is carried out by using molecular dynamics. The function equation that interfacial binding energy depends on the ratio of tin layer(the ratio of tin layer and Babbitt layer for shot) is established. Then the optimum thickness of tin interfacial layer and process control parameters can be determined based on the actual size of bushing and the formula of tin interfacial layer thickness. The experimental and simulation results show that when the tin interfacial layer thickness is 40 μm, its’ interfacial binding properties are best, and the binding strength is maximum. Meanwhile the simulation results match the tests. The formula of tin interfacial layer thickness can be directly applicable to the manufacture and repair applications of serialized product of oil-film bearing.