Nowadays, mild hypothermia is widely used in the fields of post-cardiac arrest resuscitation, stroke, cerebral hemorrhage, large-scale cerebral infarction, and craniocerebral injury. In this paper, a locally mixed sub-low temperature device is designed, and the cold and hot water mixing experiment is used to simulate the human blood transfer process. To set a foundation for the optimization of the heat transfer system, the static characteristics are analyzed by building the mathematic model and setting up the experimental station. In addition, the affection of several key structure parameters is researched. Through experimental and simulation studies, it can be concluded that, firstly, the mathematical model proved to be effective. Secondly, the results of simulation experiments show that 14.52 ￡C refrigeration can reduce the original temperature of 33.42 ￡C to 32.02 ￡C, and the temperature of refrigerated blood rises to 18.64 ￡C, and the average error is about 0.3 ￡C. Thirdly, as the thermal conductivity of the vascular sheath increases, the efficiency of the heat exchange system also increases significantly. Finally, as the input cold blood flow rate increases, the mass increases and the temperature of the mixed blood temperature decreases. It provides a research basis for subsequent research on local fixed-point sub-low temperature control technology.
Nowadays, mild hypothermia is widely used in the fields of post-cardiac arrest resuscitation, stroke, cerebral hemorrhage, large-scale cerebral infarction, and craniocerebral injury. In this paper, a locally mixed sub-low temperature device is designed, and the cold and hot water mixing experiment is used to simulate the human blood transfer process. To set a foundation for the optimization of the heat transfer system, the static characteristics are analyzed by building the mathematic model and setting up the experimental station. In addition, the affection of several key structure parameters is researched. Through experimental and simulation studies, it can be concluded that, firstly, the mathematical model proved to be effective. Secondly, the results of simulation experiments show that 14.52 ￡C refrigeration can reduce the original temperature of 33.42 ￡C to 32.02 ￡C, and the temperature of refrigerated blood rises to 18.64 ￡C, and the average error is about 0.3 ￡C. Thirdly, as the thermal conductivity of the vascular sheath increases, the efficiency of the heat exchange system also increases significantly. Finally, as the input cold blood flow rate increases, the mass increases and the temperature of the mixed blood temperature decreases. It provides a research basis for subsequent research on local fixed-point sub-low temperature control technology.
[1] Y Zhang, J Liu, Y Zhou. Pilot study on cryogenic heat transfer in biological tissues embedded with large blood vessels. Forsch Ingenieurwes, 2002, 67: 188-197.
[2] K Piironen, M Tiainen, S Mustanoja, et al. Mild hypothermia after intravenous thrombolysis in patients with acute stroke: A randomized controlled trial. Stroke, 2014, 45: 486-491.
[3] S Blowers, I Marshall, M Thrippleton, et al. How does blood regulate cerebral temperatures during hypothermia? Scientific Reports, 2018, 8: 7877.
[4] L Wu, D Wu, T Yang, et al. Hypothermic neuroprotection against acute ischemic stroke: The 2019 update. Journal of Cerebral Blood Flow & Metabolism, 2020, 40(3): 461-481.
[5] H Fei, G Cheng, A Cheng. Research status of mild hypothermia treatment of spinal cord injury. China Medical Herald, 2012, 9(9): 11-13. (in Chinese)
[6] RM Martins, JS Teodoro, E Furtado, et al. Mild hypothermia during the reperfusion phase protects mitochondrial bioenergetics against ischemia-reperfusion injury in an animal model of ex-vivo liver transplantation-an experimental study. International Journal of Medical Sciences, 2019, 16(9): 1304-1312.
[7] Nordberg P, Annoni F, Fabio TS. The impact of intra-arrest hypothermia. Current Opinion in Critical Care, 2020, 26(3): 236-241.
[8] Fukunaga, Hisanori. The effect of low temperatures on environmental radiation damage in living systems: Does hypothermia show promise for space travel? International Journal of Molecular Sciences, 2020, 21(17): 6349.
[9] L Perretta, R Reed, G Ross, et al. Is there a role for therapeutic hypothermia administration in term infants with mild neonatal encephalopathy? Journal of Perinatology, 2020, 40(3): 522-529.
[10] AM Omairi, S Pandey. Targeted hypothermia temperature management. [Updated 2020-09-10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, https://www.ncbi.nlm.nih.gov/books/NBK556124/.
[11] V A Shah, R G Geocadin. Therapeutic hypothermia in neurocritical care. In: S Nelson, P Nyquist, eds. Current clinical neurology. Humana, Cham, 19 March 2020, https://doi.org/10.1007/978-3-030-36548-6_5.
[12] H Li, X Tan, Q Xue, J H Zhu, et al. Combined application of hypothermia and medical gases in cerebrovascular diseases. Medical Gas Research, 2019, 8(4): 172-175.
[13] D Azzopardi, NJ Robertson, A Bainbridge, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): A proof-of-concept, open-label, randomized controlled trial. The Lancet Neurology, 2016, 15(2): 145-153.
[14] X Liao, Z Zhou, M Zhou, et al. Effects of endovascular and surface cooling on resuscitation in patients with cardiac arrest and a comparison of effectiveness, stability, and safety: A systematic review and a meta-analysis. CritCare, 2020, 24(1): 27.
[15] D Stanger, V Mihajlovic, J Singer, et al. Effects of targeted temperature management on mortality and neurological outcome: A systematic review and meta-analysis. European Heart Journal: Acute Cardiovascular Care, 2018, 7(5): 467-477.
[16] E Keller, H G Imhof, S Gasser, et al. Endovascular cooling with heat exchange catheters: a new method to induce and maintain hypothermia. Intensive Care Med, 2003, 29: 939-943.
[17] H M Coleridge, J C Coleridge, C Kidd. Role of the pulmonary arterial baroreceptors in the effects produced by capsaicin in the dog. Journal of Physiology, 1964, 170(170): 272.
[18] KR Martin, M Naiman, M Espinoza. Using esophageal temperature management to treat severe heat stroke: A case report. J. Neurosci. Nurs., 2020, 52(1): 9-13.
[19] J Rosman, M Hentzien, M Dramé, et al. A comparison between intravascular and traditional cooling for inducing and maintaining temperature control in patients following cardiac arrest. Anaesthesia Critical Care & Pain Medicine, 2018, 37(2): 129-134.
[20] Y Zhu, T Xiang, D Hu, et al. Protective effects of mild hypothermia against hepatic injury in rats with acute liver failure. Annals of Hepatology, 2019, 18(5): 770-776.
[21] X Zhang, X Zhao, C Zhang, et al. Improvement of neurological function and stress in patients with acute massive cerebral infarction by mild hypothermia: A prospective randomized controlled study. Chinese Critical Care Medicine, 2019, 31(8): 958-961. (in Chinese)
[22] D Azzopardi, AT Chew, A Deierl, et al. Prospective qualification of early cerebral biomarkers in a randomised trial of treatment with xenon combined with moderate hypothermia after birth asphyxia. EBioMedicine, 2019, 47: 484-491.
[23] J Caroff, R M King, J E Mitchell, et al. Focal cooling of brain parenchyma in a transient large vessel occlusion model: Proof-of-concept. Journal of NeuroInterventional Surgery, 2020, 12: 209-213.
[24] S M Seyedsaadat, S F Marasco, D J Daly, et al. Selective brain hypothermia: feasibility and safety study of a novel method in five patients. Perfusion, 2020, 35(2): 96-103.
[25] Y Lutz, T Meiner, L Krames, et al. Selective brain hypothermia for Ischemic MCA-M1 Stroke: Influence of cerebral arterial circulation in a 3D brain temperature model. IEEE Transactions on Biomedical Engineering, 2021, 68(2): 404-415.
[26] Y Wang, J H Choi, M A Almekhlafi, et al. A system for continuous Pre- to Post-reperfusion intra-carotid cold infusion for selective brain hypothermia in rodent strokemodels. Translational Stroke Research, 2020, https://doi.org/10.1007/s12975-020-00848-3.
[27] G Cattaneo, M Schumacher, J Wolfertz, et al. Meckel Combined selective cerebral hypothermia and mechanical artery recanalization in acute ischemic stroke: In vitro study of cooling performance. American Journal of Neuroradiology, 2015, 36(11): 2114-2120.
[28] T Mattingly, S Lownie. Cold blood perfusion for selective hypothermia in acute ischemic stroke. Brain Circulation, 2019, 5(4): 187-194.
[29] G Cattaneo, M Schumacher, C Maurer, et al. Meckel endovascular cooling catheter for selective brain hypothermia: An animal feasibility study of cooling performance. American Journal of Neuroradiology, 2016, 37(5): 885-891.
[30] X Xu, P Tikuisis, G Giesbrecht. A mathematical model for human brain cooling during cold-water near-drowning. Appl. Physiol., 1999, 86: 265-272.
