A high-temperature fretting wear tester was used to conduct tangential fretting wear tests of Zr-4 alloy tubes, and the effects of test temperature (25,100,200,325℃) on fretting wear behaviors under different operating conditions (complete slip region and partial slip region) were studied by changing normal load. The results show that the friction coefficient in the complete slip region was higher than that in the partial slip region at the same test temperature, and the friction coefficient at 200, 325℃ under different operating conditions reached stability earlier. In the complete slip region, the wear mechanism of the alloy included abrasive wear, oxidation wear and delamination; the increase of temperature had great influence on fretting wear degree of the alloy, and the fretting wear degree reached the maximum at 325℃. In the partial slip region, the wear mechanism included delamination, adhesive wear and oxidation wear, and the fretting wear degree was little affected by the increase of test temperature. At the same temperature, the fretting wear in the partial slip region was much lower than that in the complete slip region. The increase of test temperature had obvious effect on fretting wear amount in the complete slip region, but had little effect on that in the partial slip region.