Ti-29Nb-6Ta-5Zr-xMn(x=0,1,2,4,mass fraction/%) alloys were fabricated by nonconsumable electrode vacuum arc furnace and treated by solid solution. The effects of Mn content on the microstructure, mechanical properties and electrochemical corrosion resistance of the alloy were studied. The results show that the microstructures of all tested alloys were composed of a single β phase with equiaxed grains. The average grain size and lattice constant decreased with increasing content of Mn. The tensile strength, yield strength and hardness of the tested steel increased with increasing content of Mn and reached the largest values of 609 MPa, 585 MPa and 252 HV with 4wt% Mn, improved by 75.2%,70.1% and 58.4% comparing to those without Mn, respectively. The elongation and elastic modulus first decreased and then increased slightly with increasing content of Mn, however, the increase range was small. The corrosion potential of tested alloy containing 4wt% Mn was the highest, indicating the minimal tendency of corrosion.